The
physiological parameters most useful to the researcher are
those which provide information specifically relating to oxygen
balance (i.e. supply vs. demand) in tissues exposed to changes
in oxygen supply (i.e. during ischemia or reperfusion). In
addressing these requirements, we have developed a range of
in vivo tissue monitoring instruments that utilise fibre-optic
micro-sensors to provide real-time data for tissue oxygenation
(ptO2), tissue blood perfusion (blood flow) and
tissue temperature.
The
continuous and simultaneous measurement of tissue oxygenation
and blood perfusion (as well as temperature) from the same
sensor (and hence tissue micro-region) provides the scientist
with unique insights into a whole range of hypoxia and ischemia-related
disorders in experimental tissue and organs.
Our
instruments are employed the world over in experimental applications
covering such disciplines as tumor research, cerebral monitoring,
free-flap/pedicle-flap transfer surgery, transplantation surgery,
vital organ monitoring, pharmacology, as well as peripheral
vascular disease research.